| Literature DB >> 9873491 |
D H Steinman1, M L Curtin, R B Garland, S K Davidsen, H R Heyman, J H Holms, D H Albert, T J Magoc, I B Nagy, P A Marcotte, J Li, D W Morgan, C Hutchins, J B Summers.
Abstract
A series of succinate-derived hydroxamic acids incorporating a macrocyclic ring were designed, synthesized, and evaluated as inhibitors of matrix metalloproteinases. The inhibitors were designed based on the published X-ray crystal structure of batimastat (1) complexed with human neutrophil collagenase (MMP-8). The synthesized compounds were shown to inhibit selected MMPs in vitro with low nanomolar potency.Entities:
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Year: 1998 PMID： 9873491 DOI： 10.1016/s0960-894x(98)00396-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823