Literature DB >> 9873473

Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.

R Shirai1, H Takayama, A Nishikawa, Y Koiso, Y Hashimoto.   

Abstract

The (S,S)-enantiomer of combretadioxolane (3), designed as a chirally preorganized derivative of combretastatin A-4, exhibited quite strong tubulin polymerization-inhibitory activity (IC50: 4-6 microM). (S,S)-3 is 20 times more potent than vincristine as an in vitro growth inhibitor (in terms of GI50) of the multi-drug-resistant (MDR) cell line PC-12, which produces P-glycoprotein.

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Year:  1998        PMID： 9873473     DOI： 10.1016/s0960-894x(98)00344-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4.

Authors:  Nikhil R Madadi; Narsimha R Penthala; Kevin Howk; Amit Ketkar; Robert L Eoff; Michael J Borrelli; Peter A Crooks
Journal:  Eur J Med Chem       Date:  2015-08-29       Impact factor: 6.514

2.  Combretastatin A-4 derivatives: synthesis and evaluation of 2,4,5-triaryl-1H-imidazoles as potential agents against H1299 (non-small cell lung cancer cell).

Authors:  Chih-Hua Tseng; Chi-Yi Li; Chien-Chih Chiu; Huei-Ting Hu; Chein-Hwa Han; Yeh-Long Chen; Cherng-Chyi Tzeng
Journal:  Mol Divers       Date:  2012-09-26       Impact factor: 2.943

3.  Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents.

Authors:  Narsimha Reddy Penthala; Leena Madhukuri; Shraddha Thakkar; Nikhil Reddy Madadi; Gauri Lamture; Robert L Eoff; Peter A Crooks
Journal:  Medchemcomm       Date:  2015-06-30       Impact factor: 3.597

4.  Synthesis and biological activity of new 1,3-dioxolanes as potential antibacterial and antifungal compounds.

Authors:  Hatice Başpınar Küçük; Ayşe Yusufoğlu; Emel Mataracı; Sibel Döşler
Journal:  Molecules       Date:  2011-08-10       Impact factor: 4.411

5.  Crystal structure of 5''-(4-chloro-benzyl-idene)-4'-(4-chloro-phen-yl)-1'-methyltri-spiro[acenapthylene-1,2'-pyrrolidine-3',1''-cyclo-hexane-3'',2'''-[1,3]dioxane]-2(1H),6''-dione.

Authors:  Kuppan Chandralekha; Deivasigamani Gavaskar; Adukamparai Rajukrishnan Sureshbabu; Srinivasakannan Lakshmi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-10-03

Review 6.  Tubulin-interactive stilbene derivatives as anticancer agents.

Authors:  Renata Mikstacka; Tomasz Stefański; Jakub Różański
Journal:  Cell Mol Biol Lett       Date:  2013-07-01       Impact factor: 5.787
  6 in total

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