| Literature DB >> 9873466 |
G I Georg1, S M Ali, V J Stella, W N Waugh, R H Himes.
Abstract
The chloro-, bromo-, and iodo-derivatives 2-4 of the antimitotic drug cryptophycin 1 were synthesized by opening the epoxide ring. The biological activities of the compounds were tested in an in vitro microtubule assembly and a cell proliferation assay. The chloro-derivative 2 showed lower activity in the tubulin assay compared to 3 and 4, but they all showed similar inhibition in the proliferation assay.Entities:
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Year: 1998 PMID： 9873466 DOI： 10.1016/s0960-894x(98)00356-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823