Literature DB >> 9873445

Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.

J M Elliott1, M A Cascieri, G Chicchi, S Davies, F J Kelleher, M Kurtz, T Ladduwahetty, R T Lewis, A M MacLeod, K J Merchant, S Sadowski, G I Stevenson.   

Abstract

A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

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Year:  1998        PMID: 9873445     DOI: 10.1016/s0960-894x(98)00320-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  An efficient synthesis of a spirocyclic oxindole analogue.

Authors:  Dawei Teng; Hongxing Zhang; A Mendonca
Journal:  Molecules       Date:  2006-09-14       Impact factor: 4.411

  1 in total

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