Literature DB >> 9873426

Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard.

H H Lee1, B D Palmer, W R Wilson, W A Denny.   

Abstract

A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2-nitroimidazole from 1-methyl-2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23,862 in UV4 cells (ca. 40-fold), and superior selectivity (> 7-fold) in repair-competent AA8 cells.

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Year:  1998        PMID： 9873426     DOI： 10.1016/s0960-894x(98)00305-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

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2.  In vitro hypoxic cytotoxicity and hypoxic radiosensitization. Efficacy of the novel 2-nitroimidazole N,N,N-tris[2-(2-nitro-1H-imidazol-1-yl)ethyl]amine.

Authors:  M Langenbacher; R J Abdel-Jalil; W Voelter; M Weinmann; S M Huber
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Authors:  Michael N Levine; Ronald T Raines
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4.  Synthesis, in vitro aerobic and hypoxic cytotoxicity and radiosensitizing activity of novel metronidazole tethered 5-fluorouracil.

Authors:  Khosrou Abdi; Ali Khalaj; Seyed Nasser Ostad; Navid Lamei; Mohammad Reza Khoshayand
Journal:  Daru       Date:  2013-12-20       Impact factor: 3.117

5.  Cytotoxic effect of some 1, 4-dihydropyridine derivatives containing nitroimidazole moiety.

Authors:  Ramin Miri; Katayoun Javidnia; Zahra Amirghofran; Seyyed Hossein Salimi; Zahra Sabetghadam; Savis Meili; Ahmad Reza Mehdipour
Journal:  Iran J Pharm Res       Date:  2011       Impact factor: 1.696

6.  Cytotoxicity and radiosensitising activity of synthesized dinitrophenyl derivatives of 5-fluorouracil.

Authors:  Khosrou Abdi; Ali Khalaj; Syeed-Naser Ostad; Mohammad Reza Khoshayand
Journal:  Daru       Date:  2012-07-19       Impact factor: 3.117
  6 in total

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