Literature DB >> 9873424

Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis.

Y F Hallock1, J H Cardellina, M Schäffer, G Bringmann, G François, M R Boyd.   

Abstract

A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first "hybrid" dimer found in the Ancistrocladaceae; in vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum.

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Year:  1998        PMID： 9873424     DOI： 10.1016/s0960-894x(98)00304-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

Review 1.  Natural products as antiparasitic drugs.

Authors:  O Kayser; A F Kiderlen; S L Croft
Journal:  Parasitol Res       Date:  2003-02-20       Impact factor: 2.289

2.  Synthesis of hindered biphenyls by sequential non-transition metal-catalyzed reaction/palladium-catalyzed cross-couplings.

Authors:  Ping He; Cheng-Guo Dong; Qiao-Sheng Hu
Journal:  Tetrahedron Lett       Date:  2008-03-17       Impact factor: 2.415

3.  Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,8'-coupled monomeric alkaloids, ikelacongolines A-D, from a Congolese Ancistrocladus liana.

Authors:  Jean-Pierre Mufusama; Doris Feineis; Virima Mudogo; Marcel Kaiser; Reto Brun; Gerhard Bringmann
Journal:  RSC Adv       Date:  2019-04-16       Impact factor: 4.036

4.  Phytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae).

Authors:  Folorunso O Fasina; Oyinlola O Olaokun; Olusola O Oladipo; Margaret M Fasina; Adesoji A Makinde; Livio Heath; Armanda D S Bastos
Journal:  BMC Vet Res       Date:  2013-06-19       Impact factor: 2.741

5.  Antiplasmodial Ealapasamines A-C,'Mixed' Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis.

Authors:  Dieudonné Tshitenge Tshitenge; Doris Feineis; Virima Mudogo; Marcel Kaiser; Reto Brun; Gerhard Bringmann
Journal:  Sci Rep       Date:  2017-07-18       Impact factor: 4.379

Review 6.  Antimicrobial Importance of Medicinal Plants in Nigeria.

Authors:  Harriet U Ugboko; Obinna C Nwinyi; Solomon U Oranusi; Toluwase H Fatoki; Conrad A Omonhinmin
Journal:  ScientificWorldJournal       Date:  2020-09-22
  6 in total

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