| Literature DB >> 9873377 |
T R Belliotti1, W A Brink, S R Kesten, J R Rubin, D J Wustrow, K T Zoski, S Z Whetzel, A E Corbin, T A Pugsley, T G Heffner, L D Wise.
Abstract
PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.Entities:
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Year: 1998 PMID： 9873377 DOI： 10.1016/s0960-894x(98)00252-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823