| Literature DB >> 9871779 |
K J Barakat1, K Cheng, W W Chan, B S Butler, T M Jacks, K D Schleim, D F Hora, G J Hickey, R G Smith, A A Patchett, R P Nargund.
Abstract
A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substituent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC50 = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.Entities:
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Year: 1998 PMID： 9871779 DOI： 10.1016/s0960-894x(98)00238-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823