Literature DB >> 9871769

Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists.

B Cimetière1, T Dubuffet, O Muller, J J Descombes, S Simonet, M Laubie, T J Verbeuren, G Lavielle.   

Abstract

New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.

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Year:  1998        PMID: 9871769     DOI: 10.1016/s0960-894x(98)00220-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Endothelial dysfunction in cirrhosis: Role of inflammation and oxidative stress.

Authors:  Balasubramaniyan Vairappan
Journal:  World J Hepatol       Date:  2015-03-27

2.  Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group.

Authors:  Carlo Ballatore; Bryant Gay; Longchuan Huang; Katie Herbst Robinson; Michael J James; John Q Trojanowski; Virginia M-Y Lee; Kurt R Brunden; Amos B Smith
Journal:  Bioorg Med Chem Lett       Date:  2014-07-23       Impact factor: 2.823

3.  Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists.

Authors:  Xiaozhao Wang; Li Liu; Longchuan Huang; Katie Herbst-Robinson; Anne-Sophie Cornec; Michael J James; Shimpei Sugiyama; Marcella Bassetto; Andrea Brancale; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith; Kurt R Brunden; Carlo Ballatore
Journal:  ACS Med Chem Lett       Date:  2014-07-24       Impact factor: 4.345

Review 4.  Antiplatelet drugs--do we need new options? With a reappraisal of direct thromboxane inhibitors.

Authors:  Sergio Coccheri
Journal:  Drugs       Date:  2010-05-07       Impact factor: 9.546

Review 5.  Prostanoid receptor antagonists: development strategies and therapeutic applications.

Authors:  R L Jones; M A Giembycz; D F Woodward
Journal:  Br J Pharmacol       Date:  2009-07-15       Impact factor: 8.739

6.  Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.

Authors:  James H Soper; Shimpei Sugiyama; Katie Herbst-Robinson; Michael J James; Xiaozhao Wang; John Q Trojanowski; Amos B Smith; Virginia M-Y Lee; Carlo Ballatore; Kurt R Brunden
Journal:  ACS Chem Neurosci       Date:  2012-07-27       Impact factor: 4.418

7.  Synthesis and anticancer activity of some novel tetralin-6-yl-pyrazoline, 2-thioxopyrimidine, 2-oxopyridine, 2-thioxo-pyridine and 2-iminopyridine derivatives.

Authors:  Ebtehal S Al-Abdullah
Journal:  Molecules       Date:  2011-04-20       Impact factor: 4.411

  7 in total

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