Literature DB >> 9871763

High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.

T Harrison1, M P Korsgaard, C J Swain, M A Cascieri, S Sadowski, G R Seabrook.   

Abstract

High affinity, selective hNK2 or hNK3 ligands can be prepared from the common template 1 in a few simple chemical operations. The hNK3 ligands 3 antagonise the calcium mobilisation caused by activation of hNK3 receptors expressed in CHO cells as measured using fura-2 microspectrofluorimetry.

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Year:  1998        PMID： 9871763     DOI： 10.1016/s0960-894x(98)00215-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Pharmacophore and receptor models for neurokinin receptors.

Authors:  Anders Poulsen; Berith Bjørnholm; Klaus Gundertofte; Irina D Pogozheva; Tommy Liljefors
Journal:  J Comput Aided Mol Des       Date:  2003-11       Impact factor: 3.686

2.  A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes.

Authors:  Anders Poulsen; Tommy Liljefors; Klaus Gundertofte; Berith Bjørnholm
Journal:  J Comput Aided Mol Des       Date:  2002-04       Impact factor: 3.686

Review 3.  Current and future applications of GnRH, kisspeptin and neurokinin B analogues.

Authors:  Robert P Millar; Claire L Newton
Journal:  Nat Rev Endocrinol       Date:  2013-07-02       Impact factor: 43.330
  3 in total

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