Solid-phase synthesis of oligomeric deoxynucleic guanidine (DNG): a polycationic analogue of DNA.

DNG is a DNA analogue wherein the negatively charged phosphate backbone linkages have been replaced by achiral positively charged guanidinium linkages and has high affinity for complimentary DNA. The synthesis of these compounds in solution phase has been severely limited due to diminishing yields and solubility limitations. For the first time, an efficient solid-phase synthesis for oligomeric is reported.