| Literature DB >> 9871744 |
N J Harmat1, C Di Bugno, M Criscuoli, R Giorgi, A Lippi, A Martinelli, S Monti, A Subissi.
Abstract
A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9871744 DOI： 10.1016/s0960-894x(98)00200-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823