| Literature DB >> 9871742 |
M N Janakiraman1, K D Watenpaugh, P K Tomich, K T Chong, S R Turner, R A Tommasi, S Thaisrivongs, J W Strohbach.
Abstract
Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-related sulfonamide group. Selected bis-sulfonamide dihydropyrone analogues display high HIV protease inhibitory activity.Entities:
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Year: 1998 PMID： 9871742 DOI： 10.1016/s0960-894x(98)00197-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823