| Literature DB >> 9871723 |
M Tandon1, M Wu, T P Begley, J Myllyharju, A Pirskanen, K Kivirikko.
Abstract
Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.Entities:
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Year: 1998 PMID： 9871723 DOI： 10.1016/s0960-894x(98)00183-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823