Literature DB >> 9871709

The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins.

T A Miller1, P R Vachaspati, M A Labroli, C D Thompson, A L Bulman, T L Macdonald.   

Abstract

The synthesis and evaluation of azatoxin congeners possessing annealed aromatic frameworks are described. The compounds were evaluated for their abilities to affect topoisomerase II inhibition through the stabilization of "cleavable complex" and for the inhibition of tubulin polymerization using purified bovine brain tubulin.

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Year:  1998        PMID: 9871709     DOI: 10.1016/s0960-894x(98)00176-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Synthesis of diverse indole libraries on polystyrene resin - Scope and limitations of an organometallic reaction on solid supports.

Authors:  Kerstin Knepper; Sylvia Vanderheiden; Stefan Bräse
Journal:  Beilstein J Org Chem       Date:  2012-07-26       Impact factor: 2.883

  1 in total

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