| Literature DB >> 9871706 |
S Ducki1, R Forrest, J A Hadfield, A Kendall, N J Lawrence, A T McGown, D Rennison.
Abstract
A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'- trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.Entities:
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Year: 1998 PMID： 9871706 DOI： 10.1016/s0960-894x(98)00162-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823