| Literature DB >> 9871704 |
P Sonnet1, J Guillon, C Enguehard, P Dallemagne, R Bureau, P Rault S Auvray, S Moslemi, P Sourdiane, S Galopin, G E Séralini.
Abstract
The structure-activity relationship study of one of recently described aromatase inhibitors, compound 1 (MR20814), allowed us to design some related derivatives as potential new inhibitors. Among those we synthesized, chlorophenylpyridylmethylenetetrahydroindolizinone 5 (MR20492) exhibited in vitro a ten-fold higher inhibition of the enzyme (IC50 = 0.2 +/- 0.0 microM and Ki = 10.3 +/- 3.3 nM).Entities:
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Year: 1998 PMID： 9871704 DOI： 10.1016/s0960-894x(98)00157-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823