| Literature DB >> 9871675 |
W J Pitts1, J W Jetter, D J Pinto, M J Orwat, D G Batt, S R Sherk, J J Petraitis, I C Jacobson, R A Copeland, R L Dowling, B D Jaffee, T L Gardner, E A Jones, R L Magolda.
Abstract
The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction are related to ring system, heteroatom placement, and pendant ring substitution.Mesh：
Substances：
Year: 1998 PMID： 9871675 DOI： 10.1016/s0960-894x(98)00010-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823