Literature DB >> 9871652

New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.

I Ojima1, P Y Bounaud, C Takeuchi, P Pera, R J Bernacki.   

Abstract

New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.

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Year:  1998        PMID： 9871652     DOI： 10.1016/s0960-894x(97)10218-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

Review 1.  Drug discovery targeting cell division proteins, microtubules and FtsZ.

Authors:  Iwao Ojima; Kunal Kumar; Divya Awasthi; Jacob G Vineberg
Journal:  Bioorg Med Chem       Date:  2014-03-05       Impact factor: 3.641

2.  Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.

Authors:  Michael Jelínek; Kamila Balušíková; Petr Daniel; Vlasta Němcová-Fürstová; Palani Kirubakaran; Martin Jaček; Longfei Wei; Xin Wang; Jiří Vondrášek; Iwao Ojima; Jan Kovář
Journal:  Toxicol Appl Pharmacol       Date:  2018-04-04       Impact factor: 4.219

3.  From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.

Authors:  Daniele Castagnolo; Lorenzo Contemori; Giorgio Maccari; Stanislava I Avramova; Annalisa Neri; Gianpietro Sgaragli; Maurizio Botta
Journal:  ACS Med Chem Lett       Date:  2010-07-15       Impact factor: 4.345

4.  Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents.

Authors:  Qing Huang; Fumiko Kirikae; Teruo Kirikae; Antonella Pepe; Amol Amin; Laurel Respicio; Richard A Slayden; Peter J Tonge; Iwao Ojima
Journal:  J Med Chem       Date:  2006-01-26       Impact factor: 7.446

Review 5.  Discovery of anti-TB agents that target the cell-division protein FtsZ.

Authors:  Kunal Kumar; Divya Awasthi; William T Berger; Peter J Tonge; Richard A Slayden; Iwao Ojima
Journal:  Future Med Chem       Date:  2010-08       Impact factor: 3.808

6.  Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents.

Authors:  Kyriacos C Nicolaou; Roman A Valiulin
Journal:  Org Biomol Chem       Date:  2013-07-07       Impact factor: 3.876

7.  Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery.

Authors:  Jingyi Chen; Shuyi Chen; Xianrui Zhao; Larisa V Kuznetsova; Stanislaus S Wong; Iwao Ojima
Journal:  J Am Chem Soc       Date:  2008-12-10       Impact factor: 15.419

8.  Reversal of multidrug resistance by novel nitrophenyl pyrones, SNF4435C and D.

Authors:  K Kurosawa; K Takahashi; E Tsuda; A Tomida; T Tsuruo
Journal:  Jpn J Cancer Res       Date:  2001-11

9.  A Novel Drug Modulator Diarylheptanoid (trans-1,7-Diphenyl-5-hydroxy-1-heptene) from Curcuma comosa Rhizomes for P-glycoprotein Function and Apoptosis Induction in K652/ADR Leukemic Cells.

Authors:  Natsima Viriyaadhammaa; Suwit Duangmano; Aroonchai Saiai; Montree Tungjai; Pornngarm Dejkriengkraikul; Singkome Tima; Sawitree Chiampanichayakul; Jeffrey Krise; Songyot Anuchapreeda
Journal:  Int J Mol Sci       Date:  2022-08-12       Impact factor: 6.208
  9 in total

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