Literature DB >> 9871641

Carbocyclic frenolicin analogues: novel anticoccidial agents.

R E Armer1, C J Dutton, B R Fenner, S D Greenwood, K T Hall, A J Rudge.   

Abstract

Carbocyclic analogues of the antibacterial natural product frenolicin B have been synthesised. These analogues were active against parasitic protozoa of the genus Eimeria and represent a new series of anticoccidial agents. The synthesis of simplified analogues helped to define a possible pharmacophore for frenolicin.

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Year:  1998        PMID: 9871641     DOI: 10.1016/s0960-894x(97)10200-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

1.  In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei.

Authors:  Jay T Fitzgerald; Philipp P Henrich; Connor O'Brien; Michael Krause; Eric H Ekland; Corinna Mattheis; Juliana M Sá; David Fidock; Chaitan Khosla
Journal:  J Antibiot (Tokyo)       Date:  2011-10-19       Impact factor: 2.649

2.  A diastereoselective oxa-Pictet-Spengler-based strategy for (+)-frenolicin B and epi-(+)-frenolicin B synthesis.

Authors:  Yinan Zhang; Xiachang Wang; Manjula Sunkara; Qing Ye; Larissa V Ponomereva; Qing-Bai She; Andrew J Morris; Jon S Thorson
Journal:  Org Lett       Date:  2013-10-23       Impact factor: 6.005

3.  Frenolicins C-G, pyranonaphthoquinones from Streptomyces sp. RM-4-15.

Authors:  Xiachang Wang; Khaled A Shaaban; Sherif I Elshahawi; Larissa V Ponomareva; Manjula Sunkara; Yinan Zhang; Gregory C Copley; James C Hower; Andrew J Morris; Madan K Kharel; Jon S Thorson
Journal:  J Nat Prod       Date:  2013-08-14       Impact factor: 4.050

4.  Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host.

Authors:  Jay T Fitzgerald; Christian P Ridley; Chaitan Khosla
Journal:  J Antibiot (Tokyo)       Date:  2011-09-21       Impact factor: 2.649

5.  Total synthesis of griseusins and elucidation of the griseusin mechanism of action.

Authors:  Yinan Zhang; Qing Ye; Larissa V Ponomareva; Yanan Cao; Yang Liu; Zheng Cui; Steven G Van Lanen; S Randal Voss; Qing-Bai She; Jon S Thorson
Journal:  Chem Sci       Date:  2019-06-27       Impact factor: 9.825

  5 in total

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