| Literature DB >> 9871617 |
G Li1, W Haq, L Xiang, B S Lou, R Hughes, I A De Leon, P Davis, T J Gillespie, M Romanowski, X Zhu, A Misicka, A W Lipkowski, F Porreca, T P Davis, H I Yamamura, D F O'Brien, V J Hruby.
Abstract
Modifications of 4,4' residues of Biphalin have resulted in greater binding selectivity and biological potency for the mu opioid receptor. A higher partition coefficient across the phospholipid bilayer membrane has been achieved by using a beta-branched unusual amino acids.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9871617 DOI： 10.1016/s0960-894x(98)00065-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823