Literature DB >> 9871612

Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.

K D Stewart1, S Loren, L Frey, E Otis, V Klinghofer, K I Hulkower.   

Abstract

Using a combination of computational and combinatorial chemistry methodologies, a phenothiazine compound was discovered that is a selective inhibitor of cyclooxygenase-2 and serves as a lead compound for a potentially novel series of anti-inflammatory compounds.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9871612     DOI： 10.1016/s0960-894x(98)00068-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  In silico identification of viper phospholipaseA2 inhibitors: validation by in vitro, in vivo studies.

Authors:  Amit Nargotra; Sujata Sharma; Mohd Iqbal Alam; Zabeer Ahmed; Asha Bhagat; Subhash Chander Taneja; Ghulam Nabi Qazi; Surrinder Koul
Journal:  J Mol Model       Date:  2011-03-01       Impact factor: 1.810

2.  Chemometric rationalization of the structural and physicochemical basis for selective cyclooxygenase-2 inhibition: toward more specific ligands.

Authors:  E Filipponi; V Cecchetti; O Tabarrini; D Bonelli; A Fravolini
Journal:  J Comput Aided Mol Des       Date:  2000-03       Impact factor: 3.686
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.