| Literature DB >> 9871607 |
V Segarra1, M I Crespo, F Pujol, J Beleta, T Doménech, M Miralpeix, J M Palacios, A Castro, A Martinez.
Abstract
A 4-centre PDE4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developing PDE4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured.Entities:
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Year: 1998 PMID： 9871607 DOI： 10.1016/s0960-894x(98)00058-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823