Literature DB >> 9871598

Anti-malarial activities of acylated bruceolide derivatives.

N Murakami1, T Umezome, T Mahmud, M Sugimoto, M Kobayashi, Y Wataya, H S Kim.   

Abstract

Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl-(3c), 3,15-di-O-propionyl-(3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.

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Year:  1998        PMID： 9871598     DOI： 10.1016/s0960-894x(98)00045-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Antitrypanosomal activities of acetylated bruceines A and C; a structure-activity relationship study.

Authors:  Ahmed Elkhateeb; Yusuke Tosa; Hideyuki Matsuura; Kensuke Nabeta; Ken Katakura
Journal:  J Nat Med       Date:  2011-08-06       Impact factor: 2.343

2.  Antimalarial Natural Products.

Authors:  David G I Kingston; Maria Belen Cassera
Journal:  Prog Chem Org Nat Prod       Date:  2022

3.  Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides.

Authors:  Yasinjan Hashim; Kazufumi Toume; Shusaku Mizukami; Yue-Wei Ge; Mayumi Taniguchi; Awet Alem Teklemichael; Nguyen Tien Huy; Joseph M Bodi; Kenji Hirayama; Katsuko Komatsu
Journal:  J Nat Med       Date:  2021-06-29       Impact factor: 2.343

4.  Identification of a 3-β-homoalanine conjugate of brusatol with reduced toxicity in mice.

Authors:  Nicky Hwang; Yonggang Pei; Jason Clement; Erle S Robertson; Yanming Du
Journal:  Bioorg Med Chem Lett       Date:  2020-09-21       Impact factor: 2.823
  4 in total

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