Literature DB >> 9871594

Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates.

J D Ayers1, T L Lowary, C B Morehouse, G S Besra.   

Abstract

A series of arabinofuranosyl oligosaccharides found as constituent parts of the polysaccharide portion of the cell wall of Mycobacterium tuberculosis have been chemically synthesized. Screening of these oligosaccharides as substrates for arabinosyltransferases present in mycobacterial membrane preparations suggests that modified oligosaccharide analogs as small as disaccharides may be inhibitors of glycan biosynthesis. Such inhibitors would be of potential utility as lead compounds in the identification of new drugs for the treatment of mycobacterial infections.

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Year:  1998        PMID： 9871594     DOI： 10.1016/s0960-894x(98)00049-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Antigen 85C-mediated acyl-transfer between synthetic acyl donors and fragments of the arabinan.

Authors:  Aditya K Sanki; Julie Boucau; Donald R Ronning; Steven J Sucheck
Journal:  Glycoconj J       Date:  2008-12-04       Impact factor: 2.916

2.  Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.

Authors:  Ashish K Pathak; Vibha Pathak; William J Suling; James R Riordan; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
Journal:  Bioorg Med Chem       Date:  2008-11-18       Impact factor: 3.641

3.  On the use of 3,5-O-benzylidene and 3,5-O-(di-tert-butylsilylene)-2-O-benzylarabinothiofuranosides and their sulfoxides as glycosyl donors for the synthesis of beta-arabinofuranosides: importance of the activation method.

Authors:  David Crich; Christian Marcus Pedersen; Albert A Bowers; Donald J Wink
Journal:  J Org Chem       Date:  2007-02-08       Impact factor: 4.354

4.  Identification of a Novel Mycobacterial Arabinosyltransferase Activity Which Adds an Arabinosyl Residue to α-d-Mannosyl Residues.

Authors:  Shiva Kumar Angala; Michael R McNeil; Lu Zou; Avraham Liav; Junfeng Zhang; Todd L Lowary; Mary Jackson
Journal:  ACS Chem Biol       Date:  2016-04-08       Impact factor: 5.100

5.  Design, synthesis, and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis antigen 85C.

Authors:  Diaa A Ibrahim; Julie Boucau; Daniel H Lajiness; Sri Kumar Veleti; Kevin R Trabbic; Samuel S Adams; Donald R Ronning; Steven J Sucheck
Journal:  Bioconjug Chem       Date:  2012-12-10       Impact factor: 4.774

6.  Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids.

Authors:  Omar T Ali; Mohsin O Mohammed; Juma'a R Al Dulayymi; Mark S Baird
Journal:  Molecules       Date:  2019-10-06       Impact factor: 4.411

7.  Twenty Years of Mycobacterial Glycans: Furanosides and Beyond.

Authors:  Todd L Lowary
Journal:  Acc Chem Res       Date:  2016-06-13       Impact factor: 22.384
  7 in total

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