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Literature DB >> 9871577

X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist.

L Quéré¹, G Longfils, R Boigegrain, B Labeeuw, D Gully, F Durant.

Abstract

SR 142948 is an original and extremely potent neurotensin receptor antagonist developed in a promising approach to novel antipsychotic drugs. The X-ray structure was elucidated and compared to SR 48692 and levocabastine, providing new informations about the possible recognition process of NT receptor subtypes.

Entities: Chemical

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Year: 1998 PMID： 9871577 DOI： 10.1016/s0960-894x(98)00087-0

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

1 in total

1. The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.

Authors: James B Thomas; Angela M Giddings; Srinivas Olepu; Robert W Wiethe; Keith R Warner; Philippe Sarret; Jean-Michel Longpre; Scott P Runyon; Brian P Gilmour
Journal: Bioorg Med Chem Lett Date: 2015-04-03 Impact factor: 2.823

1 in total