| Literature DB >> 9871543 |
M Legraverend1, O Ludwig, E Bisagni, S Leclerc, L Meijer.
Abstract
The synthesis of a new family of inhibitors of the cell cycle regulating cyclin-dependent kinases (CDK's) is reported. These compounds, related to the purines olomoucine and roscovitine, are characterised by the presence of alkynylated side chains at C2. They inhibit CDK's with IC50's in the 200 nM range.Entities:
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Year: 1998 PMID： 9871543 DOI： 10.1016/s0960-894x(98)00097-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823