Literature DB >> 9871531

A new antitumor agent: methyl sulfonium perchlorate of echinomycin.

Y S Park1, Y H Kim, S K Kim, S J Choi.   

Abstract

Newly modified-echinomycin such as S-methylated sulfonium perchlorate of echinomycin (1), monosulfoxide (2), disulfoxid (3) and sulfone (4) have been prepared and evaluated for in vitro biological activities of cytotoxicity against P388, B16 and SNU-16 as well as in vivo antitumor activity against murine leukemia P388 and melanoma B16.

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Year:  1998        PMID: 9871531     DOI: 10.1016/s0960-894x(98)00113-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Echinomycin inhibits chromosomal DNA replication and embryonic development in vertebrates.

Authors:  Laurence G May; Mark A Madine; Michael J Waring
Journal:  Nucleic Acids Res       Date:  2004-01-02       Impact factor: 16.971

2.  Characterization of Streptomyces sp. LS462 with high productivity of echinomycin, a potent antituberculosis and synergistic antifungal antibiotic.

Authors:  Caixia Chen; Xiangyin Chen; Biao Ren; Hui Guo; Wael M Abdel-Mageed; Xueting Liu; Fuhang Song; Lixin Zhang
Journal:  J Ind Microbiol Biotechnol       Date:  2021-12-23       Impact factor: 4.258

  2 in total

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