| Literature DB >> 9871525 |
B E Maryanoff1, D F McComsey, G E Martin, R P Shank.
Abstract
We synthesized 20 and 21 as conformationally constrained analogues of the dopamine receptor antagonist SKF-83742, as well as analogues 6-9, 16, and 18-22. Although 20 and 21 were inactive, 7, 9, and 19 showed strong binding to D-1, D-2, S-2, and alpha-1 receptors, as well as antipsychotic activity in vivo.Entities:
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Year: 1998 PMID： 9871525 DOI： 10.1016/s0960-894x(98)00138-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823