Literature DB >> 9870903

GD3 and GM2 synthase activities in rat testes during the period of sexual development.

L L Gamallo1, V M Trindade, E A Bernard.   

Abstract

Activities of two key enzymes of gangliosides biosynthesis were determined in rat testes during development. GD3 synthase activity was low and showed small variations with age. GM2 synthase activity increased 10-fold in testes from 10- to 30-d-old animals, showing a maximum activity at 30 d, followed by a small decrease until 45 d and then a constant activity up to adulthood. These developmental changes in the activity of both glycosyltransferases were related to the increasing complexity in the ganglioside pattern observed in rats testes during the period of sexual development.

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Year:  1998        PMID： 9870903     DOI： 10.1007/s11745-998-0309-4

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  25 in total

Review 1.  Follicle-stimulating hormone, the Sertoli cell, and spermatogenesis.

Authors:  A R Means; J L Fakunding; C Huckins; D J Tindall; R Vitale
Journal:  Recent Prog Horm Res       Date:  1976

2.  Composition and synthesis of gangliosides in bovine testis, sperm and seminal plasma.

Authors:  A A Bushway; E D Clegg; T W Keenan
Journal:  Biol Reprod       Date:  1977-10       Impact factor: 4.285

Review 3.  Normal and abnormal biosynthesis of gangliosides.

Authors:  P H Fishman
Journal:  Chem Phys Lipids       Date:  1974-12       Impact factor: 3.329

4.  Biosynthesis of bovine thyroid gangliosides.

Authors:  T Pacuszka; R O Duffard; R N Nishimura; R O Brady; P H Fishman
Journal:  J Biol Chem       Date:  1978-08-25       Impact factor: 5.157

Review 5.  Gangliosides: structure, isolation, and analysis.

Authors:  R W Ledeen; R K Yu
Journal:  Methods Enzymol       Date:  1982       Impact factor: 1.600

6.  Substrate specificity of GM2 and GD3 synthase of Golgi vesicles derived from rat liver.

Authors:  D Klein; G Pohlentz; G Schwarzmann; K Sandhoff
Journal:  Eur J Biochem       Date:  1987-09-15

7.  Regulation of Sertoli cell differentiated function: testicular transferrin and androgen-binding protein expression.

Authors:  M K Skinner; S M Schlitz; C T Anthony
Journal:  Endocrinology       Date:  1989-06       Impact factor: 4.736

8.  Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system.

Authors:  K Takamiya; A Yamamoto; K Furukawa; S Yamashiro; M Shin; M Okada; S Fukumoto; M Haraguchi; N Takeda; K Fujimura; M Sakae; M Kishikawa; H Shiku; K Furukawa; S Aizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205

9.  Developmental changes in ganglioside composition and synthesis in embryonic rat brain.

Authors:  R K Yu; L J Macala; T Taki; H M Weinfield; F S Yu
Journal:  J Neurochem       Date:  1988-06       Impact factor: 5.372

10.  Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver.

Authors:  G Pohlentz; D Klein; G Schwarzmann; D Schmitz; K Sandhoff
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205
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