Literature DB >> 9870358

Characterization of oligosaccharides from an antigenic mannan of Saccharomyces cerevisiae.

M Young1, M J Davies, D Bailey, M J Gradwell, B Smestad-Paulsen, J K Wold, R M Barnes, E F Hounsell.   

Abstract

Mannans of the yeast Saccharomyces cerevisiae have been implicated as containing the allergens to which bakers and brewers are sensitive and also the antigen recognized by patients with Crohn's disease. A fraction of S. cerevisiae mannan, Sc500, having high affinity for antibodies in Crohn's patients has been characterized by NMR spectroscopy followed by fragmentation using alkaline elimination, partial acid hydrolysis and acetolysis. The released oligosaccharides were separated by gel filtration on a Biogel P4 column and analyzed by fluorescence labeling, HPLC and methylation analysis. The relationship between structure and antigen activity was measured by competitive ELISA. The antigenic activity of the original high molecular weight mannan could be ascribed to terminal Manalpha1-->3Manalpha1-->2 sequences which are rarely found in human glycoproteins but were over-represented in Sc500 compared to other yeast mannans.

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Year:  1998        PMID： 9870358     DOI： 10.1023/a:1006968117252

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  23 in total

1.  Mild acetolysis and NMR studies of the D-mannan of Saccharomyces cerevisiae X2180-1A wild-type strain.

Authors:  H Kobayashi; N Shibata; M Watanabe; M Komido; N Hashimoto; K Hisamichi; S Suzuki
Journal:  Carbohydr Res       Date:  1992-07-02       Impact factor: 2.104

2.  Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease.

Authors:  E Lindberg; K E Magnusson; C Tysk; G Järnerot
Journal:  Gut       Date:  1992-07       Impact factor: 23.059

3.  Fungal polysaccharides.

Authors:  G San-Blas; S Suzuki; V Hearn; C Pinel; H Kobayashi; C Mendez; G Niño; A Nishikawa; F San-Blas; N Shibata
Journal:  J Med Vet Mycol       Date:  1994

4.  Further characterization of IgE-binding antigens in horse dander, with particular emphasis on glycoprotein allergens.

Authors:  D B Thanh; Q Ly; B Smestad Paulsen; J K Wold
Journal:  Allergy       Date:  1996-09       Impact factor: 13.146

5.  IgE-binding components of baker's yeast (Saccharomyces cerevisiae) recognized by immunoblotting analysis. Simultaneous IgE binding to mannan and 46-48 kD allergens of Saccharomyces cerevisiae and Candida albicans.

Authors:  O Kortekangas-Savolainen; K Kalimo; K Lammintausta; J Savolainen
Journal:  Clin Exp Allergy       Date:  1993-03       Impact factor: 5.018

6.  Gastrointestinal stability of baker's yeast allergens: an in vitro study.

Authors:  O Kortekangas-Savolainen; J Savolainen; R Einarsson
Journal:  Clin Exp Allergy       Date:  1993-07       Impact factor: 5.018

7.  In vitro human lymphocyte proliferative responses to a glycoprotein of the yeast Saccharomyces cerevisiae.

Authors:  C J Darroch; S E Christmas; R M Barnes
Journal:  Immunology       Date:  1994-02       Impact factor: 7.397

8.  Structural analysis of the intact polysaccharide mannan from Saccharomyces cerevisiae yeast using 1H and 13C NMR spectroscopy at 750 MHz.

Authors:  E Vinogradov; B Petersen; K Bock
Journal:  Carbohydr Res       Date:  1998-02       Impact factor: 2.104

9.  Antibody to Saccharomyces cerevisiae (bakers' yeast) in Crohn's disease.

Authors:  J Main; H McKenzie; G R Yeaman; M A Kerr; D Robson; C R Pennington; D Parratt
Journal:  BMJ       Date:  1988-10-29

10.  Fluorescence method for the structural analysis of oligomannose-type sugar chains by partial acetolysis.

Authors:  S Natsuka; S Hase; T Ikenaka
Journal:  Anal Biochem       Date:  1987-11-15       Impact factor: 3.365
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2.  Peptide mimotopes of Mycobacterium tuberculosis carbohydrate immunodeterminants.

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3.  Cell wall polysaccharides released during the alcoholic fermentation by Schizosaccharomyces pombe and S. japonicus: quantification and characterization.

Authors:  P Domizio; Y Liu; L F Bisson; D Barile
Journal:  Food Microbiol       Date:  2016-09-10       Impact factor: 5.516

4.  Partial overlap of anti-mycobacterial, and anti-Saccharomyces cerevisiae mannan antibodies in Crohn's disease.

Authors:  Stefan Müller; Thomas Schaffer; Alain M Schoepfer; Annamarie Hilty; Thomas Bodmer; Frank Seibold
Journal:  World J Gastroenterol       Date:  2008-06-21       Impact factor: 5.742

5.  Antibodies against glucan, chitin, and Saccharomyces cerevisiae mannan as new biomarkers of Candida albicans infection that complement tests based on C. albicans mannan.

Authors:  B Sendid; N Dotan; S Nseir; C Savaux; P Vandewalle; A Standaert; F Zerimech; B P Guery; A Dukler; J F Colombel; D Poulain
Journal:  Clin Vaccine Immunol       Date:  2008-10-29

6.  Effect of dietary mannanoligosaccharide supplementation on nutrient digestibility, hindgut fermentation, immune response and antioxidant indices in dogs.

Authors:  Mahesh M Pawar; Ashok K Pattanaik; Dharmendra K Sinha; Tapas K Goswami; Kusumakar Sharma
Journal:  J Anim Sci Technol       Date:  2017-05-11

7.  Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with porcine reproductive and respiratory syndrome virus.

Authors:  T M Che; M Song; Y Liu; R W Johnson; K W Kelley; W G Van Alstine; K A Dawson; J E Pettigrew
Journal:  J Anim Sci       Date:  2012-02-24       Impact factor: 3.159
  7 in total

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