BACKGROUND: Planar gated blood pool imaging (GBPI) has long proven to be useful for the noninvasive assessment of ventricular function. From a practical viewpoint, gated blood pool single photon emission computed tomography (GBPS) acquisition can be accomplished in the same time as a three-view planar series, with the benefit of a tomographic perspective that avoids chamber overlap. METHODS AND RESULTS: Quantitative gated blood pool SPECT was applied to 10 patients who underwent coronary arteriography, contrast ventriculography, and planar gated blood pool imaging. For each patient, the mid-short axis oblique slice was divided into 4 discrete segments using 4 different reference models and 2 forms of segmentation. A center of mass (counts) fixed in the end-diastolic frame and segmentation that bisected the ventricular septum proved to have the highest sensitivity and specificity for determining regional wall motion abnormalities at rest in myocardium supplied by severely diseased coronary arteries (>75 %). GBPS correctly identified 19 of 21 abnormal segments (90%), with good specificity (95%), whereas ventriculography identified 12 (57%) and planar GBPI identified 9 (43%) of the segments supplied by diseased coronaries. CONCLUSION: Quantitative GBPS appears to be a sensitive method for assessing coronary artery disease at rest in myocardium perfused by severely diseased coronary arteries.
BACKGROUND: Planar gated blood pool imaging (GBPI) has long proven to be useful for the noninvasive assessment of ventricular function. From a practical viewpoint, gated blood pool single photon emission computed tomography (GBPS) acquisition can be accomplished in the same time as a three-view planar series, with the benefit of a tomographic perspective that avoids chamber overlap. METHODS AND RESULTS: Quantitative gated blood pool SPECT was applied to 10 patients who underwent coronary arteriography, contrast ventriculography, and planar gated blood pool imaging. For each patient, the mid-short axis oblique slice was divided into 4 discrete segments using 4 different reference models and 2 forms of segmentation. A center of mass (counts) fixed in the end-diastolic frame and segmentation that bisected the ventricular septum proved to have the highest sensitivity and specificity for determining regional wall motion abnormalities at rest in myocardium supplied by severely diseased coronary arteries (>75 %). GBPS correctly identified 19 of 21 abnormal segments (90%), with good specificity (95%), whereas ventriculography identified 12 (57%) and planar GBPI identified 9 (43%) of the segments supplied by diseased coronaries. CONCLUSION: Quantitative GBPS appears to be a sensitive method for assessing coronary artery disease at rest in myocardium perfused by severely diseased coronary arteries.
Authors: J R Corbett; D E Jansen; S E Lewis; G I Gabliani; P Nicod; N G Filipchuk; G A Redish; M S Akers; C L Wolfe; J S Rellas Journal: J Am Coll Cardiol Date: 1985-08 Impact factor: 24.094
Authors: R Sciagrà; G Bisi; P Buonamici; F Zerauschek; G M Santoro; U Meldolesi; P F Fazzini; A Pupi Journal: J Nucl Med Date: 1997-05 Impact factor: 10.057
Authors: R O Bonow; S L Bacharach; M V Green; K M Kent; D R Rosing; L C Lipson; M B Leon; S E Epstein Journal: Circulation Date: 1981-08 Impact factor: 29.690
Authors: J B Gill; R H Moore; N Tamaki; D D Miller; M Barlai-Kovach; T Yasuda; C A Boucher; H W Strauss Journal: J Nucl Med Date: 1986-12 Impact factor: 10.057
Authors: Mark W Groch; Dale J Schippers; Robert C Marshall; Paul J Groch; William D Erwin Journal: J Nucl Cardiol Date: 2002 May-Jun Impact factor: 5.952
Authors: François Harel; Vincent Finnerty; Quam Ngo; Jean Grégoire; Paul Khairy; Bernard Thibault Journal: J Nucl Cardiol Date: 2007-06-27 Impact factor: 5.952
Authors: Marcus Hacker; Xaver Hoyer; Sandra Kupzyk; Christian La Fougere; Johann Kois; Hans-Ulrich Stempfle; Reinhold Tiling; Klaus Hahn; Stefan Störk Journal: Int J Cardiovasc Imaging Date: 2005-11-22 Impact factor: 2.357
Authors: Kenneth Nichols; Rola Saouaf; Ala'eldin A Ababneh; Robyn J Barst; Marlon S Rosenbaum; Mark W Groch; Abu H Shoyeb; Steven R Bergmann Journal: J Nucl Cardiol Date: 2002 Mar-Apr Impact factor: 5.952