S Chia1, M Karim, R K Elwood, J M FitzGerald. 1. Division of TB Control, BC Center for Disease Control and Departement of Medicine, University of British Columbia, Vancouver, Canada.
Abstract
SETTING: Provincial tuberculosis (TB) and dialysis registries. OBJECTIVE: To document the risk of TB among patients on dialysis and to describe the clinical characteristics of these cases. METHODS: All cases of TB occurring among dialysis patients in British Columbia between January 1990 and December 1994 were reviewed, as were the age-specific rates for TB among the general population during the same period. RESULTS: During that period, a total of seven cases of TB occurred among 560 patients on hemo-dialysis and two cases among 326 patients on peritoneal dialysis. On an annual basis the rate of TB in the dialysis population was 253 per 100,000, compared to an age-matched rate of 10.1 per 100,000 in the general population, giving a relative risk of 25.3 (95% confidence interval 22.86-31.49, P = 0.0000001). CONCLUSIONS: The risk of TB in dialysis patients is significantly higher than previously reported from non population-based studies, indicating that dialysis patients should be considered a possible target population for systematic evaluation for the presence of TB infection and consideration for chemoprophylaxis.
SETTING: Provincial tuberculosis (TB) and dialysis registries. OBJECTIVE: To document the risk of TB among patients on dialysis and to describe the clinical characteristics of these cases. METHODS: All cases of TB occurring among dialysis patients in British Columbia between January 1990 and December 1994 were reviewed, as were the age-specific rates for TB among the general population during the same period. RESULTS: During that period, a total of seven cases of TB occurred among 560 patients on hemo-dialysis and two cases among 326 patients on peritoneal dialysis. On an annual basis the rate of TB in the dialysis population was 253 per 100,000, compared to an age-matched rate of 10.1 per 100,000 in the general population, giving a relative risk of 25.3 (95% confidence interval 22.86-31.49, P = 0.0000001). CONCLUSIONS: The risk of TB in dialysis patients is significantly higher than previously reported from non population-based studies, indicating that dialysis patients should be considered a possible target population for systematic evaluation for the presence of TB infection and consideration for chemoprophylaxis.
Authors: S S J Lee; K J Chou; I J Su; Y S Chen; H C Fang; T S Huang; H C Tsai; S R Wann; H H Lin; Y C Liu Journal: Infection Date: 2008-12-10 Impact factor: 3.553
Authors: Kevin L Winthrop; Melissa Nyendak; Helene Calvet; Peter Oh; Melanie Lo; Gwendolyn Swarbrick; Carol Johnson; Deborah A Lewinsohn; David M Lewinsohn; Gerald H Mazurek Journal: Clin J Am Soc Nephrol Date: 2008-06-11 Impact factor: 8.237
Authors: Nicolas A Menzies; Emory Wolf; David Connors; Meghan Bellerose; Alyssa N Sbarra; Ted Cohen; Andrew N Hill; Reza Yaesoubi; Kara Galer; Peter J White; Ibrahim Abubakar; Joshua A Salomon Journal: Lancet Infect Dis Date: 2018-04-10 Impact factor: 25.071