OBJECTIVE: The purpose of this study was to investigate the histologic alterations in the upper airway in patients with obstructive sleep apnea syndrome. STUDY DESIGN: Surgical specimens were obtained during non-laser-assisted uvulopalatopharyngoplasty from 5 adult patients (4 male and 1 female) with polysomnographically confirmed obstructive sleep apnea syndrome. RESULTS: In all of the specimens, interstitial edema was present with mild inflammatory reaction. Fat was not at all prominent. CONCLUSIONS: It is confirmed histologically that there is edema present in the upper airway in patients with obstructive sleep apnea syndrome. It is uncertain whether this edema is one of the causative mechanisms of the obstruction or a consequence of the syndrome.
OBJECTIVE: The purpose of this study was to investigate the histologic alterations in the upper airway in patients with obstructive sleep apnea syndrome. STUDY DESIGN: Surgical specimens were obtained during non-laser-assisted uvulopalatopharyngoplasty from 5 adult patients (4 male and 1 female) with polysomnographically confirmed obstructive sleep apnea syndrome. RESULTS: In all of the specimens, interstitial edema was present with mild inflammatory reaction. Fat was not at all prominent. CONCLUSIONS: It is confirmed histologically that there is edema present in the upper airway in patients with obstructive sleep apnea syndrome. It is uncertain whether this edema is one of the causative mechanisms of the obstruction or a consequence of the syndrome.
Authors: Takatoshi Kasai; Shveta S Motwani; Rosilene M Elias; Joseph M Gabriel; Luigi Taranto Montemurro; Naotake Yanagisawa; Neil Spiller; Narinder Paul; T Douglas Bradley Journal: J Clin Sleep Med Date: 2014-10-15 Impact factor: 4.062
Authors: Sydney C W Tang; Bing Lam; Andrew S H Lai; Clara B Y Pang; Wai Kuen Tso; Pek Lan Khong; Mary S M Ip; Kar Neng Lai Journal: Clin J Am Soc Nephrol Date: 2008-12-31 Impact factor: 8.237
Authors: Satomi Shiota; Clodagh M Ryan; Kuo-Liang Chiu; Pimon Ruttanaumpawan; James Haight; Michael Arzt; John S Floras; Christopher Chan; T Douglas Bradley Journal: Thorax Date: 2007-04-18 Impact factor: 9.139
Authors: Benjamin G Wu; Imran Sulaiman; Jing Wang; Nan Shen; Jose C Clemente; Yonghua Li; Robert J Laumbach; Shou-En Lu; Iris Udasin; Oanh Le-Hoang; Alan Perez; Shahnaz Alimokhtari; Kathleen Black; Michael Plietz; Akosua Twumasi; Haley Sanders; Patrick Malecha; Bianca Kapoor; Benjamin D Scaglione; Anbang Wang; Cameron Blazoski; Michael D Weiden; David M Rapoport; Denise Harrison; Nishay Chitkara; Eugenio Vicente; José M Marin; Jag Sunderram; Indu Ayappa; Leopoldo N Segal Journal: Am J Respir Crit Care Med Date: 2019-01-01 Impact factor: 21.405