Literature DB >> 986688

Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism.

A B Clarkson, F H Brohn.   

Abstract

When the infected mammalian host of Trypanosoma brucei brucei is injected with a solution of the iron chelator salicyl hydroxamic acid and glycerol, the aerobic and anaerobic glucose catabolism of the parasite is blocked and the parasite is rapidly destroyed.

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Year:  1976        PMID： 986688     DOI： 10.1126/science.986688

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

1.  Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei.

Authors:  S Helfert; A M Estévez; B Bakker; P Michels; C Clayton
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857

2.  Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei.

Authors:  M Bertelli; E El-Bastawissy; M H Knaggs; M P Barrett; S Hanau; I H Gilbert
Journal:  J Comput Aided Mol Des       Date:  2001-05       Impact factor: 3.686

3.  Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.

Authors:  A M Aronov; S Suresh; F S Buckner; W C Van Voorhis; C L Verlinde; F R Opperdoes; W G Hol; M H Gelb
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

4.  Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Authors:  J C Bressi; C L Verlinde; A M Aronov; M L Shaw; S S Shin; L N Nguyen; S Suresh; F S Buckner; W C Van Voorhis; I D Kuntz; W G Hol; M H Gelb
Journal:  J Med Chem       Date:  2001-06-21       Impact factor: 7.446

5.  Cryptic stage of sleeping-sickness trypanosome developing in choroid plexus epithelial cells.

Authors:  M O Abolarin; D A Evans; D G Tovey; W E Ormerod
Journal:  Br Med J (Clin Res Ed)       Date:  1982-11-13

6.  Pathogenesis of anemia in Trypanosoma brucei-infected mice.

Authors:  B O Amole; A B Clarkson; H L Shear
Journal:  Infect Immun       Date:  1982-06       Impact factor: 3.441

7.  Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs.

Authors:  T A Shapiro; P T Englund
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

8.  Relapse of monomorphic and pleomorphic Trypanosoma brucei infections in the mouse after chemotherapy.

Authors:  G D Gray; F W Jennings; S L Hajduk
Journal:  Z Parasitenkd       Date:  1982

9.  Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis.

Authors:  Fiona Achcar; Michael P Barrett; Rainer Breitling
Journal:  FEBS J       Date:  2013-08-19       Impact factor: 5.542

10.  Trypanocidal activity of antitumor antibiotics and other metabolic inhibitors.

Authors:  J Williamson; T J Scott-Finnigan
Journal:  Antimicrob Agents Chemother       Date:  1978-05       Impact factor: 5.191
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