J H Check1, C Dietterich, D Lurie, A Nazari, J Chuong. 1. University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Camden, New Jersey, USA.
Abstract
PURPOSE: The objective of the matched, controlled study was to determine whether low-dose aspirin therapy without heparin improves pregnancy rates following frozen embryo transfer. METHODS: Thirty-six women who did not achieve a pregnancy following fresh embryo transfer and who had frozen embryos available for another transfer were included. Eighteen women were treated with 81 mg aspirin from day 2 of the cycle through pregnancy testing. If the beta-human chorionic gonadotropin level was positive, aspirin was continued through the pregnancy. Eighteen women were not given aspirin. The mean outcome variables were pregnancy and implantation rates. RESULTS: The clinical pregnancy rate in the aspirin group was 11.1%, compared with 33.3% for the controls, and implantation rates were 2.9 and 10.9%, respectively. CONCLUSIONS: No positive effects of low-dose aspirin therapy on pregnancy rates following frozen embryo transfer were observed.
PURPOSE: The objective of the matched, controlled study was to determine whether low-dose aspirin therapy without heparin improves pregnancy rates following frozen embryo transfer. METHODS: Thirty-six women who did not achieve a pregnancy following fresh embryo transfer and who had frozen embryos available for another transfer were included. Eighteen women were treated with 81 mg aspirin from day 2 of the cycle through pregnancy testing. If the beta-human chorionic gonadotropin level was positive, aspirin was continued through the pregnancy. Eighteen women were not given aspirin. The mean outcome variables were pregnancy and implantation rates. RESULTS: The clinical pregnancy rate in the aspirin group was 11.1%, compared with 33.3% for the controls, and implantation rates were 2.9 and 10.9%, respectively. CONCLUSIONS: No positive effects of low-dose aspirin therapy on pregnancy rates following frozen embryo transfer were observed.
Authors: G Sher; M Feinman; C Zouves; G Kuttner; G Maassarani; R Salem; W Matzner; W Ching; P Chong Journal: Hum Reprod Date: 1994-12 Impact factor: 6.918
Authors: Bradley S Hurst; Jennifer T Bhojwani; Paul B Marshburn; Margaret A Papadakis; Terry A Loeb; Michelle L Matthews Journal: J Exp Clin Assist Reprod Date: 2005-05-31