Literature DB >> 9865601

Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes.

W M Pardridge1, J Yang, A Diagne.   

Abstract

Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 microM, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human lymphocytes, although the inhibitory effect on DNA replication is not as pronounced as is the drug inhibition of HIV-1 replication in the cells.

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Year:  1998        PMID： 9865601     DOI： 10.1016/s0165-2478(98)00096-0

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  13 in total

1.  Effect of phospholipidosis on the cellular pharmacokinetics of chloroquine.

Authors:  Nan Zheng; Xinyuan Zhang; Gus R Rosania
Journal:  J Pharmacol Exp Ther       Date:  2010-12-14       Impact factor: 4.030

2.  The ability of chloroquine to prevent tat-induced cytokine secretion by monocytes is implicated in its in vivo anti-human immunodeficiency virus type 1 activity.

Authors:  Fabienne Rayne; Agnès Vendeville; Anne Bonhoure; Bruno Beaumelle
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

3.  Antiviral activity of chloroquine against human coronavirus OC43 infection in newborn mice.

Authors:  Els Keyaerts; Sandra Li; Leen Vijgen; Evelien Rysman; Jannick Verbeeck; Marc Van Ranst; Piet Maes
Journal:  Antimicrob Agents Chemother       Date:  2009-06-08       Impact factor: 5.191

4.  Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes.

Authors:  Marloes A Naarding; Elly Baan; Georgios Pollakis; William A Paxton
Journal:  Retrovirology       Date:  2007-01-30       Impact factor: 4.602

Review 5.  Effects of chloroquine on viral infections: an old drug against today's diseases?

Authors:  Andrea Savarino; Johan R Boelaert; Antonio Cassone; Giancarlo Majori; Roberto Cauda
Journal:  Lancet Infect Dis       Date:  2003-11       Impact factor: 25.071

6.  AIDS: caused by development of resistance to drugs in a non-target intracellular parasite.

Authors:  George E Parris
Journal:  Med Hypotheses       Date:  2006-08-08       Impact factor: 1.538

7.  In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine.

Authors:  Els Keyaerts; Leen Vijgen; Piet Maes; Johan Neyts; Marc Van Ranst
Journal:  Biochem Biophys Res Commun       Date:  2004-10-08       Impact factor: 3.575

Review 8.  Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century.

Authors:  Jean-Marc Rolain; Philippe Colson; Didier Raoult
Journal:  Int J Antimicrob Agents       Date:  2007-07-16       Impact factor: 5.283

9.  Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection.

Authors:  Joachim Brouwers; Kurt Vermeire; Dominique Schols; Patrick Augustijns
Journal:  Virology       Date:  2008-07-07       Impact factor: 3.616

10.  Chloroquine interferes with dengue-2 virus replication in U937 cells.

Authors:  Kleber Juvenal Silva Farias; Paula Renata Lima Machado; Renato Ferreira de Almeida Junior; Ana Alice de Aquino; Benedito Antônio Lopes da Fonseca
Journal:  Microbiol Immunol       Date:  2014-06       Impact factor: 1.955
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