| Literature DB >> 9864403 |
S H Kurtzman1, K H Anderson, Y Wang, L J Miller, M Renna, M Stankus, R R Lindquist, G Barrows, D L Kreutzer.
Abstract
We hypothesize that interleukin 1alpha (IL-1alpha) and interleukin 1beta (IL-1beta) are present and tumor cell associated in human breast cancer (HBC) specimens. To test our hypothesis: a) immunologic analysis was performed on HBC histologic sections for IL-1alpha (n=49) and IL-1beta (n=42) distribution; and b) homogenates of HBC tumors were analyzed for levels of IL-1alpha (n=82), IL-1beta (n=101) and interleukin 8 (IL-8) (n=103) expression. Immunohistochemical analysis demonstrated the presence of IL-1alpha and IL-1beta in tumor cells in patients with invasive cancer and ductal carcinoma in situ. Quantitative analysis confirmed the presence and positive correlation of IL-1alpha and IL-1beta to IL-8, a known angiogenic factor, in cancer specimens. These studies demonstrate that tumor-associated IL-1alpha+, IL-1beta are present in the tumor microenvironment and may play a pivotal role in regulating breast tumor growth and metastasis.Entities:
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Year: 1999 PMID： 9864403 DOI： 10.3892/or.6.1.65
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906