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Literature DB >> 9864256

Identification and functional characterization of the Neisseria gonorrhoeae lbpB gene product.

G D Biswas¹, J E Anderson, C J Chen, C N Cornelissen, P F Sparling.

Abstract

We cloned lbpB, encoding a predicted 80-kDa lipoprotein, upstream of lbpA. A nonpolar mutant (LbpB- LbpA+) had normal lactoferrin (LF) binding and grew normally with LF as an iron source, whereas LbpB- LbpA- and LbpB+ LbpA- strains had reduced binding of LF and did not grow with LF as an iron source. LbpB bound LF directly in an affinity purification, suggesting that LbpB might play a still-uncharacterized role in the LF iron utilization.

Entities: Chemical Species

Mesh：

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Year: 1999 PMID： 9864256 PMCID： PMC96337

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

28 in total

1. Species-specific uptake of DNA by gonococci is mediated by a 10-base-pair sequence.

Authors: C Elkins; C E Thomas; H S Seifert; P F Sparling
Journal: J Bacteriol Date: 1991-06 Impact factor: 3.490

2. A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins.

Authors: J Ahnn; P E March; H E Takiff; M Inouye
Journal: Proc Natl Acad Sci U S A Date: 1986-12 Impact factor: 11.205

3. Iron acquisition by Haemophilus influenzae.

Authors: K A Pidcock; J A Wooten; B A Daley; T L Stull
Journal: Infect Immun Date: 1988-04 Impact factor: 3.441

Review 4. Lipoproteins in bacteria.

Authors: S Hayashi; H C Wu
Journal: J Bioenerg Biomembr Date: 1990-06 Impact factor: 2.945

5. Genetic evidence that Neisseria gonorrhoeae produces specific receptors for transferrin and lactoferrin.

Authors: K J Blanton; G D Biswas; J Tsai; J Adams; D W Dyer; S M Davis; G G Koch; P K Sen; P F Sparling
Journal: J Bacteriol Date: 1990-09 Impact factor: 3.490

6. Identification and arrangement of the DNA sequence recognized in specific transformation of Neisseria gonorrhoeae.

Authors: S D Goodman; J J Scocca
Journal: Proc Natl Acad Sci U S A Date: 1988-09 Impact factor: 11.205

7. Haemophilus influenzae can use human transferrin as a sole source for required iron.

Authors: D A Herrington; P F Sparling
Journal: Infect Immun Date: 1985-04 Impact factor: 3.441

Review 8. Microbial iron transport.

Authors: M L Guerinot
Journal: Annu Rev Microbiol Date: 1994 Impact factor: 15.500

9. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells.

Authors: R Ménard; P J Sansonetti; C Parsot
Journal: J Bacteriol Date: 1993-09 Impact factor: 3.490

10. Iron uptake from lactoferrin and transferrin by Neisseria gonorrhoeae.

Authors: W R McKenna; P A Mickelsen; P F Sparling; D W Dyer
Journal: Infect Immun Date: 1988-04 Impact factor: 3.441

26 in total

1. Specific ligand binding attributable to individual epitopes of gonococcal transferrin binding protein A.

Authors: Heather P Masri; Cynthia Nau Cornelissen
Journal: Infect Immun Date: 2002-02 Impact factor: 3.441

2. Gonococcal genes encoding transferrin-binding proteins A and B are arranged in a bicistronic operon but are subject to differential expression.

Authors: C Ronpirin; A E Jerse; C N Cornelissen
Journal: Infect Immun Date: 2001-10 Impact factor: 3.441

Identification and functional characterization of the Neisseria gonorrhoeae lbpB gene product.

1. Species-specific uptake of DNA by gonococci is mediated by a 10-base-pair sequence.

2. A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins.

3. Iron acquisition by Haemophilus influenzae.

Review 4. Lipoproteins in bacteria.

5. Genetic evidence that Neisseria gonorrhoeae produces specific receptors for transferrin and lactoferrin.

6. Identification and arrangement of the DNA sequence recognized in specific transformation of Neisseria gonorrhoeae.

7. Haemophilus influenzae can use human transferrin as a sole source for required iron.

Review 8. Microbial iron transport.

9. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells.

10. Iron uptake from lactoferrin and transferrin by Neisseria gonorrhoeae.

1. Specific ligand binding attributable to individual epitopes of gonococcal transferrin binding protein A.

2. Gonococcal genes encoding transferrin-binding proteins A and B are arranged in a bicistronic operon but are subject to differential expression.

3. Point mutations in HpuB enable gonococcal HpuA deletion mutants to grow on hemoglobin.

4. Pathogenic neisseriae can use hemoglobin, transferrin, and lactoferrin independently of the tonB locus.

5. Determination of surface-exposed, functional domains of gonococcal transferrin-binding protein A.

6. Identification of TbpA residues required for transferrin-iron utilization by Neisseria gonorrhoeae.

Review 7. Identification and characterization of gonococcal iron transport systems as potential vaccine antigens.

Review 8. Fur-mediated global regulatory circuits in pathogenic Neisseria species.

9. Identification of the iron-responsive genes of Neisseria gonorrhoeae by microarray analysis in defined medium.

10. Ferric enterobactin binding and utilization by Neisseria gonorrhoeae.