Literature DB >> 9862424

Glyoxylate cycle enzymes are present in liver peroxisomes of alloxan-treated rats.

V N Popov1, S V Volvenkin, A T Eprintsev, A U Igamberdiev.   

Abstract

Key enzymes of the glyoxylate cycle, isocitrate lyase (ICL) and malate synthase (MS), have been detected in the liver of alloxan-treated rats. The activity of ICL in rat liver was 0.040 micromol/min/mg protein and the activity of MS was 0.022 micromol/min/mg protein. These enzymes were associated with the peroxisomal fraction. The activities of citrate synthase, malate synthase and malate dehydrogenase detected in the peroxisomal fraction were also increased by alloxan treatment. Isocitrate lyase was partially purified and displayed catalytic and regulatory properties similar to those of the enzyme isolated from the liver of starved rats (Popov, V.N. et al. (1996) FEBS Lett. 391, 87-90).

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Year:  1998        PMID： 9862424     DOI： 10.1016/s0014-5793(98)01422-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

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Authors:  A V Lukovenkov; S D Varfolomeev; E E Petryaikina; I E Koltunov; N A Semenova
Journal:  Dokl Biochem Biophys       Date:  2013-05-09       Impact factor: 0.788

2.  Ensemble modeling of hepatic fatty acid metabolism with a synthetic glyoxylate shunt.

Authors:  Jason T Dean; Matthew L Rizk; Yikun Tan; Katrina M Dipple; James C Liao
Journal:  Biophys J       Date:  2010-04-21       Impact factor: 4.033

3.  Evolution of glyoxylate cycle enzymes in Metazoa: evidence of multiple horizontal transfer events and pseudogene formation.

Authors:  Fyodor A Kondrashov; Eugene V Koonin; Igor G Morgunov; Tatiana V Finogenova; Marie N Kondrashova
Journal:  Biol Direct       Date:  2006-10-23       Impact factor: 4.540

4.  Fat-to-glucose interconversion by hydrodynamic transfer of two glyoxylate cycle enzyme genes.

Authors:  P Cordero; J Campion; F I Milagro; F Marzo; J A Martinez
Journal:  Lipids Health Dis       Date:  2008-12-10       Impact factor: 3.876

5.  The proteome of human liver peroxisomes: identification of five new peroxisomal constituents by a label-free quantitative proteomics survey.

Authors:  Thomas Gronemeyer; Sebastian Wiese; Rob Ofman; Christian Bunse; Magdalena Pawlas; Heiko Hayen; Martin Eisenacher; Christian Stephan; Helmut E Meyer; Hans R Waterham; Ralf Erdmann; Ronald J Wanders; Bettina Warscheid
Journal:  PLoS One       Date:  2013-02-27       Impact factor: 3.240

6.  Glyoxylate protects against cyanide toxicity through metabolic modulation.

Authors:  Jason R Nielson; Anjali K Nath; Kim P Doane; Xu Shi; Jangwoen Lee; Emily G Tippetts; Kusumika Saha; Jordan Morningstar; Kevin G Hicks; Adriano Chan; Yanbin Zhao; Amy Kelly; Tara B Hendry-Hofer; Alyssa Witeof; Patrick Y Sips; Sari Mahon; Vikhyat S Bebarta; Vincent Jo Davisson; Gerry R Boss; Jared Rutter; Calum A MacRae; Matthew Brenner; Robert E Gerszten; Randall T Peterson
Journal:  Sci Rep       Date:  2022-03-23       Impact factor: 4.996
  6 in total

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