| Literature DB >> 9862376 |
C Couedel1, M A Peyrat, L Brossay, Y Koezuka, S A Porcelli, F Davodeau, M Bonneville.
Abstract
Human and murine natural T (NT) cells, also referred to as NK1.1+ or NK T cells, express TCR with homologous V regions (hAV24/BV11 and mAV14/BV8, respectively) and conserved "invariant" TCR AVAJ junctional sequences, suggesting recognition of closely related antigens. Murine NT cells recognize CD1-expressing cells and are activated in a CD1-restricted fashion by several synthetic alpha-glycosylceramides, such as alpha-GalCer. Here we studied the reactivity of human T cells against CD1d+ cells pulsed or not with alpha-GalCer and other related ceramides. CD1d-restricted recognition of alpha-GalCer was a general and specific feature of T cell clones expressing both BV11 and canonical AV24AJ18 TCR chains. Besides, human and murine NT cells showed the same reactivity patterns against a set of related glycosylceramides, suggesting a highly conserved mode of recognition of these antigens in humans and rodents. We also identified several AV24BV11 T cell clones self reactive against CD1+ cells of both hemopoietic and nonhemopoietic origin, suggesting the existence of distinct NT cell subsets differing by their ability to recognize self CD1d molecules.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9862376 DOI： 10.1002/(SICI)1521-4141(199812)28:12<4391::AID-IMMU4391>3.0.CO;2-2
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532