| Literature DB >> 9862140 |
S el-Mekkawy1, M R Meselhy, N Nakamura, Y Tezuka, M Hattori, N Kakiuchi, K Shimotohno, T Kawahata, T Otake.
Abstract
A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 micrograms ml-1 for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 beta-5 alpha-dihydroxy-6 beta-methoxyergosta-7,22-diene, ganoderic acid alpha, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17-0.23 mM.Entities:
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Year: 1998 PMID： 9862140 DOI： 10.1016/s0031-9422(98)00254-4
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072