Literature DB >> 986149

The cytotoxicity of plasma from patients with acute hepatic failure to isolated rabbit hepatocytes.

R D Hughes, A M Cochrane, A D Thomson, I M Murray-Lyon, R Williams.   

Abstract

The cytotoxicity of plasma from patients with various types of liver disease to rabbit hepatocytes maintained in vitro has been investigated using a microcytotoxicity assay system. Plasma from patients with fulminant hepatic failure and uncomplicated viral hepatitis showed significant cytotoxicity compared to controls. The cytotoxic effect of plasma from patients with fulminant hepatic failure was reduced by charcoal haemoperfusion, or heating and dialysis. The bile acids chenodeoxycholic acid and lithocholic acid were cytotoxic when added to control human plasma. Such toxic factors may be responsible for the delay in liver regeneration often seen in patients with fulminant hepatic failure.

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Year:  1976        PMID： 986149      PMCID： PMC2041069     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  8 in total

1.  Estimation of mouse tumour blood volumes employing a radioactive isotope technique.

Authors:  F S STEWART; A E PEARSON
Journal:  Nature       Date:  1960-04-16       Impact factor: 49.962

2.  The maintenance of liver cells in vitro for virological and other studies.

Authors:  D Rubenstein; M R Baker; E J Stott; A S Tavill
Journal:  Br J Exp Pathol       Date:  1974-02

3.  Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis.

Authors:  A D Thomson; M A Cochrane; I G McFarlane; A L Eddleston; R Williams
Journal:  Nature       Date:  1974-12-20       Impact factor: 49.962

4.  Charcoal haemoperfusion in the treatment of fulminant hepatic failure.

Authors:  B G Gazzard; M J Weston; I M Murray-Lyon; H Flax; C O Record; R Williams; B Portmann; P G Langley; E H Dunlop; P J Mellon; M B Ward
Journal:  Lancet       Date:  1974-06-29       Impact factor: 79.321

5.  Presence of hepatocyte-specific mitotic inhibitor in normal rat plasma.

Authors:  H Onda; J Yoshikawa
Journal:  Gan       Date:  1973-04

6.  Liver regeneration and uraemia.

Authors:  T S Chen; C M Leevy
Journal:  Br J Exp Pathol       Date:  1973-12

7.  Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage.

Authors:  B G Gazzard; B Portmann; I M Murray-Lyon; R Williams
Journal:  Q J Med       Date:  1975-10

8.  The fine structure, potassium content, and respiratory activity of isolated rat liver parenchymal cells prepared by improved enzymatic techniques.

Authors:  R B Howard; J C Lee; L A Pesch
Journal:  J Cell Biol       Date:  1973-06       Impact factor: 10.539
  8 in total
  18 in total

Review 1.  Prospects for extracorporeal liver support.

Authors:  R Jalan; S Sen; R Williams
Journal:  Gut       Date:  2004-06       Impact factor: 23.059

2.  Inhibitors of hepatic DNA synthesis in fulminant hepatic failure.

Authors:  R D Hughes; H Yamada; C D Gove; R Williams
Journal:  Dig Dis Sci       Date:  1991-06       Impact factor: 3.199

3.  Response of porcine hepatocytes in primary culture to plasma from severe viral hepatitis patients.

Authors:  Yong-Bo Cheng; Ying-Jie Wang; Shi-Chang Zhang; Jun Liu; Zhi Chen; Jia-Jia Li
Journal:  World J Gastroenterol       Date:  2005-12-28       Impact factor: 5.742

Review 4.  Liver regeneration in relationship to acute liver failure.

Authors:  C D Gove; R D Hughes
Journal:  Gut       Date:  1991-09       Impact factor: 23.059

5.  Inhibitory activity of the serum from patients with fulminant hepatitis against liver regeneration.

Authors:  K Tada; K Akamatsu; Y Ohta
Journal:  Gastroenterol Jpn       Date:  1986-06

6.  Progress in the management of fulminant hepatic failure.

Authors:  S Braude; A E Gimson; R Williams
Journal:  Intensive Care Med       Date:  1981-04       Impact factor: 17.440

7.  Mechanisms responsible for antibody-dependent, cell-mediated cytotoxicity to isolated hepatocytes in chronic active hepatitis.

Authors:  C Gonzales; A M Cochrane; A L Eddleston; R Williams
Journal:  Gut       Date:  1979-05       Impact factor: 23.059

Review 8.  Clinical application of bioartificial liver support systems.

Authors:  Maarten Paul van de Kerkhove; Ruurdtje Hoekstra; Robert A F M Chamuleau; Thomas M van Gulik
Journal:  Ann Surg       Date:  2004-08       Impact factor: 12.969

9.  Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation.

Authors:  Ting Wang; Yasuhiro Takikawa; Asako Watanabe; Keisuke Kakisaka; Kanta Oikawa; Kanta Oigawa; Yasuhiro Miyamoto; Kazuyuki Suzuki
Journal:  J Gastroenterol       Date:  2013-12-22       Impact factor: 7.527

10.  Lymphocyte cytotoxicity in chronic active hepatitis: effect of therapy and correlations with clinical and histological changes.

Authors:  A M Cochrane; A Moussouros; A Smith; B Portmann; A L Eddleston; R Williams
Journal:  Gut       Date:  1978-04       Impact factor: 23.059
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