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Literature DB >> 9860977

A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells.

E M Garabedian¹, P A Humphrey, J I Gordon.

Abstract

A transgenic mouse model of metastatic prostate cancer has been developed that is 100% penetrant in multiple pedigrees. Nucleotides -6500 to +34 of the mouse cryptdin-2 gene were used to direct expression of simian virus 40 T antigen to a subset of neuroendocrine cells in all lobes of the FVB/N mouse prostate. Transgene expression is initiated between 7 and 8 weeks of age and leads to development of prostatic intraepithelial neoplasia within a week. Prostatic intraepithelial neoplasia progresses rapidly to local invasion. Metastases to lymph nodes, liver, lung, and bone are common by 6 months. Tumorigenesis is not dependent on androgens. This model indicates that the neuroendocrine cell lineage of the prostate is exquisitely sensitive to transformation and provides insights about the significance of neuroendocrine differentiation in human prostate cancer.

Entities: Disease Gene Species

Mesh：

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Year: 1998 PMID： 9860977 PMCID： PMC28051 DOI： 10.1073/pnas.95.26.15382

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

30 in total

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Journal: Expert Rev Respir Med Date: 2011-10 Impact factor: 3.772

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Journal: Cancer Metastasis Rev Date: 2014-09 Impact factor: 9.264

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Authors: Laurie E Littlepage; Mark D Sternlicht; Nathalie Rougier; Joanna Phillips; Eugenio Gallo; Ying Yu; Kurt Williams; Audrey Brenot; Jeffrey I Gordon; Zena Werb
Journal: Cancer Res Date: 2010-03-09 Impact factor: 12.701