BACKGROUND: Many studies have reported that obstetric complications are risk factors for schizophrenia, but few studies have examined whether complications increase risk for bipolar disorder. METHODS: Bipolar-disorder probands and their adult siblings were diagnosed using DSM-III-R criteria. Obstetrical data from maternal reports were scored, blind to diagnosis, applying published scales that take into account number and severity of complications. RESULTS: Obstetric complication scores were significantly worse in probands than siblings without mood disorders. LIMITATIONS: Probands had relatively severe symptoms; research using more heterogeneous samples is needed. CONCLUSION: Results suggest obstetric complications are etiologically significant in bipolar disorder.
BACKGROUND: Many studies have reported that obstetric complications are risk factors for schizophrenia, but few studies have examined whether complications increase risk for bipolar disorder. METHODS:Bipolar-disorder probands and their adult siblings were diagnosed using DSM-III-R criteria. Obstetrical data from maternal reports were scored, blind to diagnosis, applying published scales that take into account number and severity of complications. RESULTS: Obstetric complication scores were significantly worse in probands than siblings without mood disorders. LIMITATIONS: Probands had relatively severe symptoms; research using more heterogeneous samples is needed. CONCLUSION: Results suggest obstetric complications are etiologically significant in bipolar disorder.
Authors: Aditya Ambati; Ryan Hillary; Smaranda Leu-Semenescu; Hanna M Ollila; Ling Lin; Emmanuel H During; Neal Farber; Thomas J Rico; Juliette Faraco; Eileen Leary; Andrea N Goldstein-Piekarski; Yu-Shu Huang; Fang Han; Yakov Sivan; Michel Lecendreux; Pauline Dodet; Makoto Honda; Natan Gadoth; Sona Nevsimalova; Fabio Pizza; Takashi Kanbayashi; Rosa Peraita-Adrados; Guy D Leschziner; Rosa Hasan; Francesca Canellas; Kazuhiko Kume; Makrina Daniilidou; Patrice Bourgin; David Rye; José L Vicario; Birgit Hogl; Seung Chul Hong; Guiseppe Plazzi; Geert Mayer; Anne Marie Landtblom; Yves Dauvilliers; Isabelle Arnulf; Emmanuel Jean-Marie Mignot Journal: Proc Natl Acad Sci U S A Date: 2021-03-23 Impact factor: 11.205
Authors: J M Goldstein; S Cherkerzian; S L Buka; G Fitzmaurice; M Hornig; M Gillman; S O'Toole; R P Sloan Journal: J Dev Orig Health Dis Date: 2011-12 Impact factor: 2.401