Literature DB >> 9856953

p53-independent role of MDM2 in TGF-beta1 resistance.

P Sun1, P Dong, K Dai, G J Hannon, D Beach.   

Abstract

Transforming growth factor-beta (TGF-beta) inhibits cell proliferation, and acquisition of TGF-beta resistance has been linked to tumorigenesis. A genetic screen was performed to identify complementary DNAs that abrogated TGF-beta sensitivity in mink lung epithelial cells. Ectopic expression of murine double minute 2 rescued TGF-beta-induced growth arrest in a p53-independent manner by interference with retinoblastoma susceptibility gene product (Rb)/E2F function. In human breast tumor cells, increased MDM2 expression levels correlated with TGF-beta resistance. Thus, MDM2 may confer TGF-beta resistance in a subset of tumors and may promote tumorigenesis by interference with two independent tumor suppressors, p53 and Rb.

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Year:  1998        PMID： 9856953     DOI： 10.1126/science.282.5397.2270

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  49 in total

Review 1.  Mdm2: the ups and downs.

Authors:  T Juven-Gershon; M Oren
Journal:  Mol Med       Date:  1999-02       Impact factor: 6.354

Review 2.  TGF-beta signaling in mammary gland development and tumorigenesis.

Authors:  L M Wakefield; E Piek; E P Böttinger
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-01       Impact factor: 2.673

Review 3.  Integration of the pRB and p53 cell cycle control pathways.

Authors:  C L Stewart; A M Soria; P A Hamel
Journal:  J Neurooncol       Date:  2001-02       Impact factor: 4.130

4.  MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon.

Authors:  N Vlatkovic; S Guerrera; Y Li; S Linn; D S Haines; M T Boyd
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

5.  PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway.

Authors:  Naoto Yoshizuka; Maoyi Lai; Rong Liao; Ryan Cook; Changchun Xiao; Jiahuai Han; Peiqing Sun
Journal:  Mol Cancer Res       Date:  2012-06-04       Impact factor: 5.852

Review 6.  Genetic analysis of CD28 signaling.

Authors:  Tiffani A Greene; Virginia Smith Shapiro
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

7.  p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage.

Authors:  Chia-Cheng Wu; Xiaohua Wu; Jiahuai Han; Peiqing Sun
Journal:  Protein Cell       Date:  2010-06       Impact factor: 14.870

8.  Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein β.

Authors:  Dechen Fu; Neena Lala-Tabbert; Hwabin Lee; Nadine Wiper-Bergeron
Journal:  J Biol Chem       Date:  2015-02-26       Impact factor: 5.157

9.  MDM2 regulates dihydrofolate reductase activity through monoubiquitination.

Authors:  Maria Maguire; Paul C Nield; Timothy Devling; Rosalind E Jenkins; B Kevin Park; Radoslaw Polański; Nikolina Vlatković; Mark T Boyd
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

10.  Association of v-ErbA with Smad4 disrupts TGF-beta signaling.

Authors:  Richard A Erickson; Xuedong Liu
Journal:  Mol Biol Cell       Date:  2009-01-14       Impact factor: 4.138
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