Literature DB >> 9856950

Requirement for IL-13 independently of IL-4 in experimental asthma.

G Grünig1, M Warnock, A E Wakil, R Venkayya, F Brombacher, D M Rennick, D Sheppard, M Mohrs, D D Donaldson, R M Locksley, D B Corry.   

Abstract

The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell-deficient mice by an IL-4 receptor alpha chain-dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.

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Year:  1998        PMID： 9856950      PMCID： PMC3897229          DOI： 10.1126/science.282.5397.2261

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  32 in total

1.  IL-13 production by allergen-stimulated T cells is increased in allergic disease and associated with IL-5 but not IFN-gamma expression.

Authors:  S Till; S Durham; R Dickason; D Huston; J Bungre; S Walker; D Robinson; A B Kay; C Corrigan
Journal:  Immunology       Date:  1997-05       Impact factor: 7.397

2.  Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.

Authors:  H Mitsuyasu; K Izuhara; X Q Mao; P S Gao; Y Arinobu; T Enomoto; M Kawai; S Sasaki; Y Dake; N Hamasaki; T Shirakawa; J M Hopkin
Journal:  Nat Genet       Date:  1998-06       Impact factor: 38.330

3.  IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.

Authors:  J F Urban; N Noben-Trauth; D D Donaldson; K B Madden; S C Morris; M Collins; F D Finkelman
Journal:  Immunity       Date:  1998-02       Impact factor: 31.745

4.  The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.

Authors:  G K Hershey; M F Friedrich; L A Esswein; M L Thomas; T A Chatila
Journal:  N Engl J Med       Date:  1997-12-11       Impact factor: 91.245

5.  A critical role for IL-13 in resistance to intestinal nematode infection.

Authors:  A J Bancroft; A N McKenzie; R K Grencis
Journal:  J Immunol       Date:  1998-04-01       Impact factor: 5.422

6.  The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1.

Authors:  D D Donaldson; M J Whitters; L J Fitz; T Y Neben; H Finnerty; S L Henderson; R M O'Hara; D R Beier; K J Turner; C R Wood; M Collins
Journal:  J Immunol       Date:  1998-09-01       Impact factor: 5.422

7.  A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5.

Authors:  S P Hogan; K I Matthaei; J M Young; A Koskinen; I G Young; P S Foster
Journal:  J Immunol       Date:  1998-08-01       Impact factor: 5.422

8.  Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.

Authors:  D B Corry; G Grünig; H Hadeiba; V P Kurup; M L Warnock; D Sheppard; D M Rennick; R M Locksley
Journal:  Mol Med       Date:  1998-05       Impact factor: 6.354

9.  Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses.

Authors:  M Barner; M Mohrs; F Brombacher; M Kopf
Journal:  Curr Biol       Date:  1998-05-21       Impact factor: 10.834

10.  Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production.

Authors:  L Cohn; R J Homer; A Marinov; J Rankin; K Bottomly
Journal:  J Exp Med       Date:  1997-11-17       Impact factor: 14.307
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  543 in total

Review 1.  IgE in asthma and atopy: cellular and molecular connections.

Authors:  H C Oettgen; R S Geha
Journal:  J Clin Invest       Date:  1999-10       Impact factor: 14.808

Review 2.  Immune mechanisms of childhood asthma.

Authors:  C E Donovan; P W Finn
Journal:  Thorax       Date:  1999-10       Impact factor: 9.139

Review 3.  Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation.

Authors:  A Ray; L Cohn
Journal:  J Clin Invest       Date:  1999-10       Impact factor: 14.808

Review 4.  Cytokines in asthma.

Authors:  K F Chung; P J Barnes
Journal:  Thorax       Date:  1999-09       Impact factor: 9.139

Review 5.  Science, medicine, and the future. Allergic disorders.

Authors:  S T Holgate
Journal:  BMJ       Date:  2000-01-22

Review 6.  Th1/Th2 balance in atopy.

Authors:  T Biedermann; M Röcken
Journal:  Springer Semin Immunopathol       Date:  1999

Review 7.  The diverse effects of mast cell mediators.

Authors:  Colleen Hines
Journal:  Clin Rev Allergy Immunol       Date:  2002-04       Impact factor: 8.667

Review 8.  Chemokines in allergic lung inflammation.

Authors:  Clare Lloyd
Journal:  Immunology       Date:  2002-02       Impact factor: 7.397

9.  IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production.

Authors:  H Ochi; N H De Jesus; F H Hsieh; K F Austen; J A Boyce
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

10.  IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice.

Authors:  Timothy B Oriss; Mahesh Raundhal; Christina Morse; Rachael E Huff; Sudipta Das; Rachel Hannum; Marc C Gauthier; Kathryn L Scholl; Krishnendu Chakraborty; Seyed M Nouraie; Sally E Wenzel; Prabir Ray; Anuradha Ray
Journal:  JCI Insight       Date:  2017-05-18
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