Literature DB >> 9856482

Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger.

J E Tucker1, R J Winkfein, S K Murthy, J S Friedman, M A Walter, D J Demetrick, P P Schnetkamp.   

Abstract

The retinal rod Na-Ca+K exchanger is a unique calcium extrusion protein found only in the outer segments of retinal rod photoreceptors. Rod Na-Ca+K exchanger cDNA (NCKX1) has been cloned from bovine and human retinas. Here, we have used fluorescent in situ hybridization and radiation hybrid mapping to localize the human NCKX1 gene to chromosome 15q22. We have determined the genomic organization of human rod NCKX1 and found one intron in the 5' untranslated region and eight introns within the coding region.

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Year:  1998        PMID: 9856482     DOI: 10.1007/s004390050842

Source DB:  PubMed          Journal:  Hum Genet        ISSN: 0340-6717            Impact factor:   4.132


  1 in total

1.  Molecular cloning and functional expression of the potassium-dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors.

Authors:  C F Prinsen; R T Szerencsei; P P Schnetkamp
Journal:  J Neurosci       Date:  2000-02-15       Impact factor: 6.167

  1 in total

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