OBJECTIVE: To determine the accuracy of a screening examination for distal sensory peripheral neuropathy (DSPN) performed by nonphysician clinicians and to explore the associations between DSPN and clinical features in HIV-infected persons. METHODS: A case-control study of a volunteer sample of 226 HIV-infected individuals was performed. An interview, focusing on risks and symptoms of DSPN, and a screening neurologic examination were performed. RESULTS: Compared with the neurologist's examinations, the clinicians' examination was sensitive (92 to 95%) but not as specific (71 to 84%) for the diagnosis of DSPN. After excluding 27 patients with confounders, 42 of 199 patients (21%) had DSPN. This was associated significantly with neurotoxic nucleoside antiretroviral use and with more advanced HIV disease. Of the 42 patients with DSPN, 30 (71%) had no neuropathy symptoms. CONCLUSIONS: A brief examination performed by trained nonphysician clinicians can be used to screen for DSPN in HIV-infected persons. Asymptomatic DSPN is common in these individuals.
OBJECTIVE: To determine the accuracy of a screening examination for distal sensory peripheral neuropathy (DSPN) performed by nonphysician clinicians and to explore the associations between DSPN and clinical features in HIV-infectedpersons. METHODS: A case-control study of a volunteer sample of 226 HIV-infected individuals was performed. An interview, focusing on risks and symptoms of DSPN, and a screening neurologic examination were performed. RESULTS: Compared with the neurologist's examinations, the clinicians' examination was sensitive (92 to 95%) but not as specific (71 to 84%) for the diagnosis of DSPN. After excluding 27 patients with confounders, 42 of 199 patients (21%) had DSPN. This was associated significantly with neurotoxic nucleoside antiretroviral use and with more advanced HIV disease. Of the 42 patients with DSPN, 30 (71%) had no neuropathy symptoms. CONCLUSIONS: A brief examination performed by trained nonphysician clinicians can be used to screen for DSPN in HIV-infectedpersons. Asymptomatic DSPN is common in these individuals.
Authors: Alejandro Arenas-Pinto; Jennifer Thompson; Godfrey Musoro; Hellen Musana; Abbas Lugemwa; Andrew Kambugu; Aggrey Mweemba; Dickens Atwongyeire; Margaret J Thomason; A Sarah Walker; Nicholas I Paton Journal: J Neurovirol Date: 2015-08-25 Impact factor: 2.643
Authors: Alyssa C Vecchio; Christina M Marra; Jeffrey Schouten; Hongyu Jiang; Johnstone Kumwenda; Khuanchai Supparatpinyo; James Hakim; Ned Sacktor; Thomas B Campbell; Srikanth Tripathy; Nagalingeswaran Kumarasamy; Alberto La Rosa; Breno Santos; Marcus T Silva; Cecilia Kanyama; Cindy Firnhaber; Mina C Hosseinipour; Rosie Mngqibisa; Colin Hall; Paola Cinque; Kevin Robertson Journal: Clin Infect Dis Date: 2020-06-24 Impact factor: 9.079
Authors: Ronald J Ellis; Scott R Evans; David B Clifford; Lauren R Moo; Justin C McArthur; Ann C Collier; Constance Benson; Ron Bosch; David Simpson; Constantin T Yiannoutsos; Yijun Yang; Kevin Robertson Journal: J Neurovirol Date: 2005-12 Impact factor: 2.643
Authors: V Valcour; T-M Yeh; R Bartt; D Clifford; M Gerschenson; S R Evans; B A Cohen; G J Ebenezer; P Hauer; L Millar; M Gould; P Tran; C Shikuma; S Souza; J C McArthur Journal: HIV Med Date: 2009-02 Impact factor: 3.180