| Literature DB >> 9855194 |
J O Hollinger1, J M Schmitt, D C Buck, R Shannon, S P Joh, H D Zegzula, J Wozney.
Abstract
The study reported describes a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and collagen (C) to regenerate bone. Unilateral critical-sized defects (CSDs) were prepared in radii of 32 skeletally mature New Zealand white rabbits. Rabbits were divided evenly among four treatments: autograft, absorbable C (Helistat), 35 microg of rhBMP-2 combined with absorbable C (rhBMP-2/C), and untreated CSDs. The two euthanasia periods were 4 and 8 weeks. Radiographs were taken the day of surgery, every 2 weeks, and at term and the percent of radiopacity was measured. Data analysis revealed a time-dependent increase in the percent radiopacity with rhBMP-2/C. Histological examination revealed the rhBMP-2/C treatment regenerated osseous contour by 8 weeks. According to quantitative histomorphometry, the CSD and C groups had significantly less new bone than either autograft or rhBMP-2/C (p < or = 0.05). The results suggest that rhBMP-2/C could be an effective therapy to restore segmental bone defects.Entities:
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Year: 1998 PMID： 9855194 DOI： 10.1002/(sici)1097-4636(199824)43:4<356::aid-jbm3>3.0.co;2-7
Source DB: PubMed Journal: J Biomed Mater Res ISSN： 0021-9304